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Five young children and their 34-year-old father are feared to be dead after a large fire destroyed their family home on Russell Island, in Brisbane's south-east, this morning.
Speaking to the media, Superintendent Mat Kelly said a 28-year-old woman, believed to be their mother, escaped the blaze.
Kelly confirmed the fire, which spread to multiple houses on Todman Street at Russell Island, was not being treated as suspicious.
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Police said the missing siblings were aged between 3-11, and included twins boys, aged four.
"The house has been burnt to the ground," Kelly told media.
"These young boys who could have been men in the future and a man has lost his life.
"We are still speaking with this poor lady who has lost her entire family."
Thick plumes of thick smoke were seen billowing into the sky, after the house became engulfed in blames about 6.20am this morning.
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Firefighters rushed to the scene after receiving multiple triple zero calls, where they found the mother crying for help.
"They were greeted with a distressed lady and a house fully alight," Kelly said.
Nine people were treated at the scene by paramedics and two people have been taken to Redlands Hospital in a stable condition.
The tragedy has sent shock waves through the community, Kelly said.
"(Russell Island) is a very small ingrained community," he said.
"They all support each other and they are devastated by this."
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Firefighters remain on the scene and are working to suppress the fire, a Queensland Fire and Emergency Services spokesperson previously told 9news.com.au.
One of the structures has been extinguished, one has completely collapsed and one is still alight.
Police have established a crime scene as the search continues for those missing.
Investigations are underway to determine the cause of the fire and police have appealed to anyone with information or relevant vision to come forward.
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