Matthew Perry's death has been declared as accidental, the County of Los Angeles Department of Medical Examiner has confirmed.
Perry's death was caused by "acute effects of ketamine," which caused him to drown.
"At the high levels of ketamine found in his postmortem blood specimens, the main lethal effects would be from both cardiovascular overstimulation and respiratory depression," the report states.
Perry was "reported to be receiving ketamine infusion therapy for depression and anxiety," the autopsy report states.
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The medical examiner also pointed to coronary artery disease and the effects of buprenorphine, a prescribed drug, as contributing factors to his death.
You can read the full judgement below.
"The County of Los Angeles Department of Medical Examiner (DME) determined the cause of death for 54-year-old actor Matthew Langford Perry as the acute effects of ketamine," the medical examiner said in a statement.
"On October 29, the deputy medical examiner completed an autopsy on Perry.
"Following the completion and receipt of relevant test results, the cause and manner of death were certified.
"The manner of death is accident."
Perry's last known treatment was a week and a half prior to his death, the autopsy states, well beyond the time it would still be in his system from the treatment.
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Ketamine is a dissociative drug, used both medically and recreationally.
The Friends star was open about his struggles with addiction, detailing his uphill climb to sobriety in his 2022 memoir, Friends, Lovers, and the Big Terrible Thing.
Perry was vocal about wanting to help others through addiction and was an advocate for treatment instead of incarceration for drug-related offences.
Perry was found unresponsive in a hot tub in his backyard on October 28.
He rose to fame on the hit 90s sitcom Friends, playing the charming and hilarious Chandler Bing.
Perry was 'happy' and 'heathy' before his death
The autopsy report this week notes that Perry had reportedly not used drugs for 19 months before his death.
It also states that though he was a "heavy tobacco user for many years," he was not a smoker when he died.
His "Friends" costar Jennifer Aniston said this month that she had been in contact with Perry on the day of his death, and that he "was happy."
"I was literally texting with him that morning, funny Matty," she said in an interview with Variety.
"He was not in pain. He wasn't struggling."
"He was happy. He was healthy," she added.
"He had quit smoking. He was getting in shape."
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County of Los Angeles Department of Medical Examiner full statement
The County of Los Angeles Department of Medical Examiner (DME) determined the cause of death for 54-year-old actor Matthew Langford Perry as the acute effects of ketamine. Contributing factors in Mr. Perry's death include drowning, coronary artery disease and the effects of buprenorphine (used to treat opioid use disorder). The manner of death is accident.
On October 28, at approximately 1600 hours, Mr. Perry was found unresponsive in the pool at his residence. After 911 was called, paramedics responded to the scene and death was pronounced.
DME responded, conducted a scene investigation and then transported Mr. Perry's body to the DME's Forensic Science Center for examination.
On October 29, the deputy medical examiner completed an autopsy on Mr. Perry. Following the completion and receipt of relevant test results, the cause and manner of death were certified.
If you or someone you know would like to talk to someone confidentially about addiction, contact Lifeline on 13 11 14 or visit Reach Out. In an emergency, call 000.