Six killed in horror outback highway crash

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Six people have died after a four-wheel-drive and a road train collided on a highway south of Darwin in one of the worst road crashes in the territory's history.

The crash occurred on the Stuart Highway near Pine Creek in the Katherine on Friday before both vehicles burst into flames.

Police said work is under way to identify the six people and inform their families.

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Six people have been killed on a highway - south of Darwin in what police have called the Northern Territory's deadliest crash in 16 years.

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The driver and passenger of the heavy vehicle was treated for non-life-threatening injuries.

Northern Territory Police Detective Senior Sergeant Brendan Lindner said first responders were faced with "a confronting crash".

"I would like to commend the work of all those involved in this tragic incident, including those first on scene who quickly contacted emergency services," Lindner said.

Nineteen people have lost their lives on Northern Territory roads so far this year.